Analysis of 11 candidate genes in 849 adult patients with suspected hereditary cancer predisposition
نویسندگان
چکیده
منابع مشابه
Hereditary Pancreatic Cancer: Part II. Candidate Genes
This special series on cancer and genetics is compiled and edited by Henry T. Lynch, MD, director of the Hereditary Cancer Institute, professor of medicine, and chairman of the Department of Preventive Medicine and Public Health, Creighton University School of Medicine, and director of the Creighton Cancer Center, Omaha, Nebraska. Part I of this three-part series on pancreatic cancer appeared i...
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BACKGROUND Hereditary nonpolyposis colorectal cancer syndrome (HNPCC syndrome; also called Lynch syndrome) is one of the most common cancer predisposition syndromes. Most cases of cancer associated with this syndrome are due to the inheritance of germline mutations in genes that encode proteins required for DNA mismatch repair; defects in these proteins allow mutations to accumulate more rapidl...
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ژورنال
عنوان ژورنال: Genes, Chromosomes and Cancer
سال: 2020
ISSN: 1045-2257,1098-2264
DOI: 10.1002/gcc.22911